Gender differences in left ventricular geometry and determinants of myocardial perfusion reserve in patients with severe aortic stenosis

Methods Forty-one patients with isolated severe AS without obstructive coronary artery disease underwent adenosine stress perfusion CMR in a 1.5T scanner (Siemens Avanto); MPR was calculated from absolute myocardial blood flow during adenosine hyperaemia and rest determined by model-independent deconvolution of signal intensity curves with an arterial input function. Transthoracic echocardiography was used to assess AS severity, tissue Doppler derived diastolic function, LVRPP (LV rate pressure product=[systolic blood pressure (SBP) + peak aortic valve gradient]*heart rate) an estimate of myocardial work, and diastolic perfusion time (DPT=[R-R interval LV ejection time]*heart rate).